2026
- Mouse Dish or Human?4 min read
An 80-year-old's blood cells were made 60 years 'younger' in a dish. A dish result is a dish result.
Researchers at the University of Bonn announced today, in Aging Cell, that they had converted blood-cell precursors from an 80-year-old donor directly into neural stem cells and watched the cells' epigenetic age — the DNA-methylation clock reading — fall to under 20 years over…
- Mouse Dish or Human?4 min read
Mouse, dish or human? Semaglutide extended lifespan in old female mice by 92 days.
A paper in Nature today, with a same-day release from the National Institutes of Health, reports that semaglutide — the molecule in Wegovy — given to female mice from 20 months of age extended their median lifespan from 742 days to 834, about 12%.
- Evidence · Mouse Dish or Human?4 min read
A model says the ceiling on human life is 146 to 194 years. A model is a model.
A paper published last month in npj Aging is making the rounds this week under headlines about living to 190. The authors built a mathematical model in which the body is a chain of critical organs, each losing cells to lethal mutations over time, and asked how long a person would…
- Evidence · Mouse Dish or Human?4 min read
The first reprogramming therapy is cleared for a human trial. 'Cleared to test' and 'shown to work' are different sentences.
Life Biosciences announced today that the FDA has cleared its investigational new drug application for ER-100, which the company describes as the first cellular rejuvenation therapy using epigenetic reprogramming to be allowed into human trials.